Nonetheless, NuRD subunits are part of the ER interactome in breast cancer cells even in the absence of tamoxifen treatment (83) and multiple recent reports have linked this complex with the GATA family transcription factor trichorhinophalangeal syndrome type I (TRPS1), which is frequently amplified in breast and prostate cancer (74, 85-88). The gene discussed is ESR1; the disease is breast cancer.