Schechter et al. (2015) found that parenting stress negatively correlates with the levels of NR3C1 methylation in children. Another study demonstrated lower NR3C1 exon 1F methylation in patients with generalized anxiety disorder with a history of ACEs (Wang et al., 2017). Lower methylation of the NR3C1 has also been found in adults who lost their only child (Qi et al., 2020). Differences in previous studies might originate from assessment of various CpG sites in the NR3C1 gene, heterogeneity of self-reports used for recording ACEs, and inclusion of various clinical populations. The gene discussed is NR3C1; the disease is generalized anxiety disorder.