Furthermore, in line with the enhanced virus replication, we detected that SFTSV infection in the Mov10-KD animals (but not the control) significantly induced platelet count reduction (Fig 4E) and alanine transaminase (ALT) level increase (an indicator of liver dysfunction) (Fig 4F), which both are major clinical features of human infection with SFTSV. Here, GPT is linked to Decreased liver function.