NLRC4 and macrophage activation syndrome: Furthermore, to compare gene expression profiles between HS patients and other defined SAID patients, we obtained and analyzed published transcriptome data from individuals diagnosed with either neonatal onset multisystem inflammatory disease (NOMID), NLRC4 macrophage activation syndrome (NLRC4-MAS) or A20 haploinsufficiency (due to mutation of TNFAIP3) [20, 21] (GSE57253 and GSE95078).