APC and acute myeloid leukemia: Myeloid leukemias are frequently characterized by cohesin mutations, particularly in STAG2. Furthermore, activation of Wnt signaling is associated with transformation in AML (Wang et al., 2010; Beghini et al., 2012; Kang et al., 2020) and AML patients were identified with mutations in AXIN1 and APC that lead to stabilization of β-catenin (Erbilgin et al., 2012).