SMC1A and cancer: To determine if stabilization of β-catenin is conserved in a second model of cohesin-mutant cancer, we performed an identical LY2090314 treatment on HCT116 cells that were stably transfected to express two SMC1A mutations identified in human colorectal carcinomas, c.2027A > G (leading to p.E676G change near the hinge domain) and c.2479 C > T (leading to a truncated protein, p.Q827X) (Cucco et al., 2014; Sarogni et al., 2019).