VSMC-specific deletion of the most abundant subtype (AT1aR) did not affect aortic pathology in Fbn1mgR/mgR mice [131], nor in an ascending aortic aneurysm model (LDL receptor−/− mice fed a saturated fat diet and infused with Ang II) [132]. The gene discussed is AGTR1; the disease is Ascending tubular aorta aneurysm.