MAPK3 and aortic aneurysm: Of these kinases, particularly ERK1/2 seems to be involved in aortic aneurysm formation, as the MAPK kinase (MEK) 1/2 inhibitor RDEA119 attenuated aortic root growth by selectively reducing ERK1/2 activation in Fbn1C1041G+ mice, without affecting JNK and p38 activity [38].