In the univariate analysis, we found that age (HR = 1.039, 95% CI: 1.006-1.074, and P = 0.020), Gleason score (HR = 1.629, 95% CI: 1.329-1.997, and P < 0.001), stage (HR = 1.693, 95% CI: 1.051-2.726, and P = 0.030), SIRT3 (HR = 0.999, 95% CI: 0.998-1.000, and P = 0.014), and SIRT6 (HR = 0.999, 95% CI: 0.997-1.000, and P = 0.037) were all independent risk factors for OS of PCa patients (Supplementary Table 2). Here, SIRT6 is linked to posterior cortical atrophy.