As shown in Figure 1(a), higher mRNA levels of SIRT3, SIRT6, and SIRT7 were observed in the PCa samples compared with those of the normal tissues (HR, CI P = 3.30E − 03; HR, CI P = 2.35E − 08; and HR, CI P = 9.20E − 08). Here, SIRT6 is linked to posterior cortical atrophy.