In our present study, we found that both the mRNA and protein expression levels of SIRT3 and SIRT6 are significantly increased in the PCa tissues (HR, CI P = 3.30E − 03; HR, CI P = 2.35E − 08; and HR, CI P = 9.20E − 08) and were associated with patients' Gleason score and nodal metastasis. Here, SIRT3 is linked to posterior cortical atrophy.