Immunosuppressive cells (e.g., myeloid-derived suppressor cells (MDSCs) and regulatory T (Treg) cells) are recruited to the TME by chemotactic factors derived from tumor, stromal, or other immune cells and convey negative signals to the antitumor immune cells via the expression of inhibitory ligands (e.g., programmed death-ligand 1 (PD-L1)) and the secretion of immunosuppressive factors (e.g., interleukin 10 (IL-10), transforming growth factor-beta (TGF-b), and prostaglandin E2 (PGE 2)). This evidence concerns the gene IL10 and neoplasm.