IGFBP6 encourages migration in rhabdomyosarcoma cells via mediating the MAP kinase signaling pathway [53], while IGFBP6 plays a suppressive role on tumor growth in ACTH-secreting pituitary adenoma through activation of the PI3K-AKT-mTOR signaling pathway [54]. Here, AKT1 is linked to pituitary gland adenoma.