Numerous researches have pointed out that the IGFBP3 overexpression is also in relation with the favorable survival in lung cancer [34], hepatocellular carcinoma [35], breast cancer [36], bladder carcinoma [37], esophageal squamous cell cancer [38], and pancreatic ductal adenocarcinoma [39]. Here, IGFBP3 is linked to esophageal squamous cell carcinoma.