MyD88−/−, Il1r1−/−, and IL-23R KO and conditional (CD2-cre; Raptorfl/fl, CD-2-cre;Rictorfl/fl and CD-2-cre;Stat3fl/fl) KO mice  Human subjects with psoriasis vulgaris  Psoriasis-like mouse model. The gene discussed is CD2; the disease is psoriasis vulgaris.