Our data also indicates that Vdac2 expression is positively correlated with cognitive health as it is downregulated in the folate-deficient mice (2.3-fold down; P = 0.035; Supplementary Table 3) which is consistent with lower Vdac2 protein levels in the brains of AD patients (64) yet were shown to be elevated in the brains of an AD mouse model (65, 66). Here, VDAC2 is linked to Alzheimer disease.