Neutrophil-derived S100A8/A9 subsequently interacts with TLR-4 on cardiac/circulating neutrophils, priming the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in neutrophils and facilitating the secretion of interleukin (IL) 1 (IL-1β) in murine models of MI (Sreejit et al., 2020). Here, S100A8 is linked to myocardial infarction.