HE initially possess morphologic and transcriptional characteristics of vascular ECs before undergoing a transition to hematopoietic progenitor cells, a process commonly referred to as the endothelial to hematopoietic transition, which is orchestrated by hematopoietic-specifying transcription factors primarily driven by Runx1 (Sugiyama et al., 2003; Frame et al., 2016; Kasaai et al., 2017; Yzaguirre et al., 2017). This evidence concerns the gene RUNX1 and hereditary elliptocytosis.