Changes in SLs metabolism are a hallmark of different neurodegenerative disorders, including AD (Alaamery et al., 2020; Crivelli et al., 2020), and drugs targeting S1P and its receptors (O’Sullivan and Dev, 2017) or lowering ceramide levels (Brodowicz et al., 2018) have been claimed as potentially useful for the treatment of AD. The gene discussed is MBTPS1; the disease is Alzheimer disease.