In addition, HDAC5 played an important role in inhibiting expression of the genes participating in angiogenesis including CYR61, PVRL2, FSTL1, and Slit2 in patients with systemic sclerosis, which could be reversed by silencing of HDAC5 (Urbich et al., 2009; Tsou et al., 2016). This evidence concerns the gene HDAC5 and systemic sclerosis.