LRP2 can increase the proliferation of neural precursor cells in the subependymal zone (Gajera et al., 2010) and the proliferation and survival of skin cancer cells (Andersen et al., 2015), however, it is unclear whether cells of the OL lineage express LRP2 (Cahoy et al., 2008; Zhang et al., 2014; Hrvatin et al., 2018), or whether Lrp1 deletion could alter LRP2 expression. Here, LRP2 is linked to skin neoplasm.