In our pilot study (Acevedo-Villanueva et al., 2020) experiment 1: following two oral delivered very high doses of nanovaccine (500, 1,000, and 2,000 μg antigen in CS NPs) and S. Enteritidis challenge infection detected induction of high levels of nitrite production in macrophages and secretion of antigen specific IgG and IgA antibodies at early time points. Here, CD79A is linked to infection.