FLG and Alzheimer disease: Variants in genes involved in maintenance of skin integrity (FLG, ACTL9, SPINK5) and inflammation (TNFA, IL10, IL13) have previously been found associated with AD (Kato et al., 2003; Bussmann et al., 2011; Lesiak et al., 2011; Paternoster et al., 2011; Behniafard et al., 2012; Portelli et al., 2015; Bauer, 2017; Kim and Leung, 2018).