CD8A and neoplasm: To examine whether the GFAP+ enteric glia could be promoting tumor development through suppression of CD8+ T cell or NK cell activity, we depleted CD8+ T cells (Figure S3A) or NK cells (Figure S3B) from enteric-glia-depleted AOM/DSS mice, using anti-CD8α and anti-NK1.1 antibodies, respectively, to determine whether the beneficial effect of enteric glia depletion was dependent on these cells.