The disease activity index (Figure 3A), body weight loss (Figure 3B), neutrophil tissue infiltration (Figure 3C), colon length (Figure 3D), and histopathology score (Figures 3E, F) of the enteric-glia-depleted mice were all unchanged compared to control mice, indicating that GFAP+ enteric glia do not contribute significantly to the development of DSS-induced colitis. This evidence concerns the gene GFAP and colitis.