The univariate analysis revealed that previous anti-VEGFR agents (hazard ratio [HR], 2.423; 95% CI, 1.245–4.715; P = 0.009), NLR (HR, 1.976; 95% CI, 1.061–3.682; P = 0.032), and hand-foot syndrome (HFS) (HR, 2.153; 95% CI, 1.077–4.304; P = 0.030) were significantly associated with PFS. Here, KDR is linked to Hand-foot syndrome.