When coupled to the pseudomonas exotoxin A (ETA), the PCNSL-binding epitope of SAMD14/neurabin-I (hereafter referred to only as neurabin-I) confers cytotoxic effects against DLBCL cells transfected with neurabin-I-specific BCRs in vitro. The gene discussed is PPP1R9A; the disease is diffuse large B-cell lymphoma.