Frustratingly, autophagy is widely reported to be used to protect tumor cells from chemotherapeutic effects through down-regulation of oxidative stress and ER stress, up-regulation of mitochondrial function, and stress tolerance, among which the cellular pathways mainly contain PI3K/Akt/mTOR, MAPK/Erk/mTOR and p53/genotoxic stress (5–7). This evidence concerns the gene MTOR and neoplasm.