To ascertain whether SFRP1 is involved in miR-27a-related EMT, via the Wnt/β-catenin pathway in NSCLC cells, we co-transfected mimics and inhibitors of miR-27a with siSFRP1 in A549 and H1299 cells. The gene discussed is SFRP1; the disease is non-small cell lung carcinoma.