(24) investigated a large cohort of HB patients, and demonstrated that overexpression and hypomethylation of genes in the 14q32 DLK1-DIO3 imprinted region, which includes the largest known cluster of miRNAs and snoRNAs in the human genome, is associated with HB patient outcome, and activation of the Wnt/beta-catenin pathway. Here, DIO3 is linked to hemoglobin measurement.