Interestingly, our results resemble recent findings within a stem-like subtype of HCC, which is known to be associated with overexpression of miRNAs located in this cluster (23), and they are also very similar to a recent report showing that genes in the DLK1-DIO3 imprinted region are hypomethylated and overexpressed in HB, enabling stratification of patient outcomes (24). Here, DLK1 is linked to hepatocellular carcinoma.