Previous studies have shown that IOP can change energy metabolism through the LKB1/AMPK pathway and induce lung cancer cell apoptosis [18]; IOP can also reduce the expression of MMP-2 and MMP-9 by downregulating the NF-κB signaling pathway, thereby inhibiting the migration and invasion of B16-F10 cells [19]. The gene discussed is MMP9; the disease is lung cancer.