AKT1 and pachyonychia congenita: Accumulating evidence has implied that the PI3K-Akt signaling pathway promotes malignant processes of PDAC cells, including proliferation, angiogenesis, metastasis, suppression of apoptosis, and chemoresistance, and targeting the PI3K-Akt signaling pathway has been a potential therapeutic strategy for the treatment of PC (Ebrahimi et al., 2017).