CTLA4 and ovarian neoplasm: Blocking PD-1 alone was shown to be insufficient in controlling murine ovarian tumor growth but dual blocking of the PD-1-LAG-3 or PD-1-CTLA-4 cascades could delay murine ovarian tumor growth, and blocking 3 PD-1-CTLA-4-LAG-3 cascades was superior if the PD-1 pathway was entirely blocked (Huang et al., 2017).