Many glycosyltransferases such as N-acetylglucosaminyltransferase V (GnT-V), N-acetylglu-cosaminyltransferase III (GnT-III) and α1-6 fucosyltransferase (FUT8) have been considered to be related to the development of HCC. The gene discussed is FUT8; the disease is hepatocellular carcinoma.