Although the interaction relationships between hsa-miR-224 and PRPF4B, as well as between hsa-miR-31 and NR3C2/PPP6C have not been experimentally demonstrated previously, the function studies on these target genes in cancers may indirectly reveal the possible roles of hsa-miR-224 and hsa-miR-31. The gene discussed is PPP6C; the disease is cancer.