Notably, quercetin decreased plasma levels of signal transducer and activator of transcription 3 (STAT3) and IL-6 in ApcMin/+ mice, which is a model of cachexia with colorectal cancer (Moser et al., 1990), thus implying that quercetin inactivates the IL-6/STAT3 signaling pathway (Velázquez et al., 2014). This evidence concerns the gene STAT3 and colorectal cancer.