This pattern of co‐expression of IFN‐γ and IL‐10 together with an absence of FOXP3 expression has been observed in CD4+ T cells from children living in malaria‐endemic regions who have suffered recent malarial episodes16, 17, 18 and is associated with a type 1 regulatory T‐cell phenotype (TR1) (reviewed in Roncarolo et al. 19, 20). This evidence concerns the gene CD4 and malaria.