In absence of ex vivo stimulation by TLR‐L, we observed a higher production of IL‐12p40/p70 by circulating and tumor‐infiltrating cDC2s and of IFNα and IFNλ1 by tumor‐infiltrating pDCs and cDC1s, respectively, compared to HD (increase in both proportion of positive DCs and total amount of cytokine secreted). The gene discussed is IFNA1; the disease is neoplasm.