In absence of ex vivo stimulation by TLR‐L (condition ‘stim –’), we observed a higher production of IL‐12p40/p70 by circulating and tumor‐infiltrating cDC2s and of IFNα and IFNλ1 by tumor‐infiltrating pDCs and cDC1s, respectively, compared to HD. The gene discussed is IFNA1; the disease is neoplasm.