Even though productions of TNFα and IFNα were slightly impaired, respectively, in circulating cDC2s and pDCs upon R848 and mix TLR stimulation, production of IL‐12p40/p70 by circulating cDC2s, TNFα or/and IFNλ1 by circulating pDCs and cDC1s remained similar to HD. The gene discussed is IFNL1; the disease is Huntington disease.