In absence of ex vivo stimulation by TLRL, we observed significant increased secretions of IL12p70, IFNα, IFNβ and IFNλ2 in patient blood, and increased productions of IFNβ, IFNλ1 and IFNλ2 in tumors when compared to the control group (Figure 7), further demonstrating the basal activation of DCs within tumor microenvironment. Here, IFNL1 is linked to neoplasm.