Some interactions between type I and III IFNs seen in HD were preserved in tumors of patients, whereas new ones occurred, such as between IFNλ1/IFNλ2 and IFNβ (mix) or IFNα/IFNβ and IFNλ2 (polyI:C), underlying that cDC1s, whose functionality is poorly affected by the tumor, might positively impact pDCs. This evidence concerns the gene IFNL1 and neoplasm.