Despite impairments of productions of TNFα and IFNα, respectively, by circulating cDC2s and pDCs, production of IL‐12p40/p70 by circulating cDC2s together with TNFα and/or IFNλ1 respectively by circulating or tumor‐infiltrating cDC1s and pDCs remained similar to HD. Here, IFNA1 is linked to Huntington disease.