In this study we performed analysis of overall survival for high grade glioma (anaplastic astrocytoma/grade III and glioblastoma / grade IV) that received same standard treatment (surgical resection, radiation and temozolomide) based on its prognostic marker; IDH1 mutation, MGMT methylation and PD-L1 expression. This evidence concerns the gene IDH1 and anaplastic astrocytoma.