This study aims to review further the effect of Zhuang-Gu-Fang on the ultrastructure of osteoblasts, bone metabolism balance, and serum Leptin, Ghrelin, and PYY concentration in ovariectomized rats and explore the treatment of postmenopausal osteoporosis with Zhuang-Gu-Fang-related mechanisms. Here, GHRL is linked to postmenopausal osteoporosis.