CDK1 and myocardial infarction: The overexpression of four regulatory factors of cell cycle including CDK1 was shown to efficiently induce cell division in postmitotic mouse, rat, and human cardiomyocytes, lead to a significant improvement in cardiac function after acute or subacute myocardial infarction, and improve heart function as indicated by significant improvement in the ejection fraction, stroke volume, and cardiac output.