Bedİr et al. (2020) found that the PON3 level decreased significantly in patients with PCa. They also found that PON3 increased postoperatively in those with PCa. They proposed that surgical excision of malignant tissue in PCa caused a decrease in oxidative stress and that a higher level of PON3 was associated with lower oxidative stress (Bedİr et al., 2020). Finally, IGSF1 is a novel oncogene regulating the progression of thyroid cancer (Guan et al., 2019); however, no study describing its role in PCa has been reported. The gene discussed is PON3; the disease is thyroid gland carcinoma.