This inhibition is credited to the lowered expression of Runx2 by the association of lncRNA-ANCR and enhancer of zeste homolog 2 (EZH2; Cai et al., 2019), whereas the elevated expression of lncRNA UCA1 in the plasma of osteoporosis patients inhibited osteoblast function. This evidence concerns the gene RUNX2 and osteoporosis.