The results indicated that four variants were significantly related to the sepsis risk at a nominal level: rs2297518, located in the NOS2 gene (OR = 1.53, 95%CI = 1.12–2.10, P = 0.01); rs10865710, located in the PPARG gene (OR = 1.32, 95%CI = 1.06–1.63, P = 0.01); rs740598, located in the HSPA12A gene (OR = 1.25, 95%CI = 1.01–1.53, P = 0.04); and rs5743551, located in the TLR1 gene (OR = 1.26, P = 0.04). Here, NOS2 is linked to Sepsis.