Therefore, those genetic variants exhibited a strong association with initiation and augmentation of sepsis (Arcaroli et al., 2005; Namath and Patterson, 2011), such as the TLR1-7202A/G (rs5743551) and TLR2 Asn248Ser (rs4833095) polymorphisms which have affected the function of TLR genes and TNFA-308G/A (rs1800629) and IL6-572C/G (rs1800796) which have affected the expression level of cytokine TNF-α and IL-6, respectively (Wurfel et al., 2008; Duan et al., 2011). Here, TNF is linked to Sepsis.