IFNG and neoplasm: Overall, the dimeric architecture of the IFNγ/IFNGR1/IFNGR2 complex is critical for inducing the full spectrum of IFNγ-mediated pleotropic activities (108), which includes macrophage activation (109, 110), tumor surveillance (111, 112), and protection from intracellular pathogens, including mycobacteria (50, 113).