Many strategies such as expressing chemokine receptors CXCR2/CCR2b, CXCR3 and use of oncolytic virus to secrete chemokines RANTES, IL-15 to drive CART cells to tumor sites are being actively tested to drive CART cells to tumor sites in non-GBM tumors (147–149). The gene discussed is CXCR2; the disease is neoplasm.