RO60 and systemic lupus erythematosus: Among the many reasons to suspect that L1 plays a role in autoimmune disease is the observation that ORF1p resides mostly in macromolecular assemblies (Figure 2) that have been proposed to be stress granules (87) together with L1 RNA and other RNA-binding proteins (88–91), such as Ro60, La (92), and U1 small nuclear ribonucleoprotein of 70 kDa (88), all well-established autoantigens in SLE and related diseases.