We recently reported that SLE patients also frequently have autoantibodies against the L1-encoded ORF1p protein (181), which is physically associated with Ro, La, snRNP70, and other well-known SLE autoantigens (87, 88, 91, 182) together with RNA in macromolecular assemblies (which may be stress-granules). The gene discussed is CALR; the disease is systemic lupus erythematosus.