EGFR and neoplasm: In contrast, cetuximab increased the induction of Ifnβ expression in human SCC6 cells following 8 Gy radiation in vitro (Figure 2I), suggesting that the radiosensitizing effects of cetuximab may further enhance the type I interferon response induced by radiation in tumor cells that are sensitive to cetuximab-mediated blockade of EGFR signaling.