We found that various tumor tissues, including those of diffuse large B cell lymphoma (DLBCL), expressed higher levels of 4-1BB ligand mRNA (Supplementary Figure 7), suggesting that our novel 4-1BB expressing CAR-T cells may benefit from 4-1BB ligand enrichment in various tumor microenvironments. This evidence concerns the gene TNFRSF9 and diffuse large B-cell lymphoma.