Most of the linear AMPs composed entirely of natural L-amino acids currently in phase II or III clinical trials are intended for external administration, such as omiganan for the treatment of rosacea and severe inflammatory acne vulgaris, LL37 for hard-to-heal venous leg ulcers, and pexiganan for diabetic foot ulcers (Costa et al., 2019). The gene discussed is ADSL; the disease is diabetic foot.