Effectively blocking CXCR4 might therefore interfere with tumor growth and metastasis in ACC in vivo, as also highlighted by the inhibitory effect of the CXCR4 antagonist AMD3100 on the proliferation and migration of the human ACC cell line NCI-H295 reported by Kitawaki et al. (42). Here, CXCR4 is linked to adrenal cortex carcinoma.