CXCR4 mRNA levels in NCI-H295 were similar to those found in ACC (p=0.06) and normal adrenals (p=0.13), whereas CXCR7 mRNA levels in NCI-H295 were significantly lower compared to both ACC (46-fold lower, p<0.01) and normal adrenals (11-fold lower, p<0.01). This evidence concerns the gene CXCR4 and adrenal cortex carcinoma.