Extended analyzes of the expression of both chemokine receptors and their common ligand CXCL12 not only in primary tumors but also in matched metastases together with functional studies on ACC cell lines are warranted to receive a better insight into the impact of CXCR4 and CXCR7 on the prognosis of ACC. The gene discussed is CXCR4; the disease is adrenal cortex carcinoma.