However, we recognize that a high number of pancreatic islets with different degrees of inflammation and pancreata from recent-onset T1D donors showing highly infiltrated islets are needed to adequately characterize ACE2 expression in the early stages of the disease and to determine whether changes in ACE2 expression contribute to: (i) the observed alteration of glycaemic control at admission in SARS-CoV-2 individuals without previous clinical history of diabetes; (ii) the increased severity of COVID-19 in those subjects with previous inflammatory-based diseases. Here, ACE2 is linked to type 1 diabetes mellitus.