ACE2 and type 2 diabetes mellitus: In line with these observations, neither primary human islets exposed to palmitate (47) nor human islets isolated from patients affected by type 2 diabetes (48) and evaluated by RNA sequencing showed any increase in ACE2 mRNA expression as compared to the respective controls [respectively 0.9 control vs 0.5 palmitate and 2.4 control vs 3.5 T2D; data reported as Trimmed Means of M values (TMM); not significant].