In human adipose tissue and liver, ChREBP-β mRNA levels correlate with the expression of ChREBP target genes (15, 28, 29), and in adipose tissue ChREBP-β levels also correlate with insulin sensitivity (28, 29) whereas in liver raised ChREBP expression correlates with insulin resistance (29), most likely because ChREBP target genes include G6pc and Gckr (23, 27, 30), and induction of these genes predicts impaired hepatic glucose clearance (9). This evidence concerns the gene MLXIPL and Insulin resistance.