Most of the studies using ChREBP knock-down models have provided evidence for a protective role for ChREBP in liver function (Figure 2), particularly during challenge with a fructose-containing diet (52–56) or in other compromised metabolic states such as glucose 6-phosphatase deficiency (57). The gene discussed is G6PC1; the disease is hyperinsulinemic hypoglycemia, familial, 4.