MLXIPL and hyperinsulinemic hypoglycemia, familial, 4: Studies on LiChREBP-/- models from three independent groups have shown that during challenge with high-fructose or high-sucrose diets the ChREBP deficiency in liver associates with raised plasma alanine aminotransferase (ALAT) activity, a marker of hepatocyte damage, establishing a protective role for hepatic ChREBP in fructose metabolism (17, 54, 55).