Prior to the discovery of the ChREBP-β isoform, ChREBP mRNA levels in liver or isolated hepatocytes were found to be modestly (< 2-fold) raised in conditions of markedly elevated glucose 6-P as occurs in experimental models of high glucose or glucose 6-phosphatase deficiency (22). The gene discussed is MLXIPL; the disease is hyperinsulinemic hypoglycemia, familial, 4.