GH1 and acromegaly: Among pituitary tumors, the growth hormone (GH)-secreting ones (somatotropinomas) account for about 15%–20% of cases, causing gigantism in children/adolescents while in adults leads to the clinical picture of acromegaly characterized by overgrowth of bone and cartilages, and cardiovascular, metabolic, respiratory and neoplastic complications (1–3).