Among pituitary tumors, the growth hormone (GH)-secreting ones (somatotropinomas) account for about 15%–20% of cases, causing gigantism in children/adolescents while in adults leads to the clinical picture of acromegaly characterized by overgrowth of bone and cartilages, and cardiovascular, metabolic, respiratory and neoplastic complications (1–3). This evidence concerns the gene GH1 and pituitary tumor.