In addition, dual-specificity phosphatase (DUSPs) acts specifically on JNK and p38, and studies have shown that the PPARγ agonist rosiglitazone induces phosphorylation of p38 and JNK MAPK in neurons, and inhibits neuronal apoptosis in an animal model of cerebral ischemia, which was mainly achieved by promoting the upregulation of DUSP8 and Bcl-xl (79). Here, MAPK8 is linked to brain ischemia.