Paradoxically, Qin et al., reported that SOCS3-deleted macrophages had higher levels of the M1 genes IL-1b, IL-6, IL-12, IL-23, and iNOS and exacerbated LPS-induced sepsis in LysMCre-SOCS3fl/fl mice which lacked SOCS3 in myeloid lineage cells (14). The gene discussed is SOCS3; the disease is Sepsis.